Medications

Phentermine -Lomaira- Diethylpropion-Phendimetrazine  are the medications in this category. These are short term amphetamine like medications That increase energy and metabolism by increasing the blood pressure and heart rate. Use is recommended for less than 3 months due to their addiction potential and the development of tolerance. Expect to lose an average of 5-10 % of your initial body weight after 3 months.

This is a combination stimulant appetite suppressant that combines phentermine and topiramate (a seizure medication). Qsymia is approved for long term use and is considered the most effective stimulant oral medication.  With a strong ability to reduce appetite and portion sizes, expect to lose an average of 10-15% of initial body weight.

Contrave ( naltrexone and bupropion) is a nonstimulant appetite suppressant. This long term medication is best for controlling cravings and emotional eating. Expect to lose around 5-10% of initial body weight with Contrave therapy. 

Wegovy ( Semaglutide) is a GLP-1 agonist that helps you feel full sooner and stay full longer. If you want significant weight loss, choose a GLP-1 like Wegovy. Patients lose an average of 15-17% of their body weight at maximum dose (2.4mg) after 1 year. Wegovy is also available in a daily pill with comparable weight loss to the injection. Wegovy HD (7.2 mg) was recently approved to increase average weight loss to up to 20%. 

This is the most effective FDA approved weight loss medication as of 2026. It combines the GLP-1 agonist and GIP to help feel full longer and control hunger. Weight loss results average up to 20% after 1 year of therapy on the 15 mg max dose. 

Foundayo is a daily non-peptide GLP-1 agonist taken as a pill. This tablet is preferred if you desire to take a GLP-1 pill without constraints of taking on an empty stomach. Average weight loss on the maximum dose of 17.2 mg after 1 year is around 11%.